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oai:hju.repo.nii.ac.jp:00000740 2023-09-13T07:26:39Z 1747705089129:161:171

尿のアルカリ化による尿中尿酸排泄量の増加の栄養学的意義 Significance of Nutritional Intervention for Treatment of Hyperuricemia and Gout 神原, 彩 カンバラ, アヤ 瀨山, 一正 セヤマ, イッセイ Kanbara, Aya Seyama, Issei 栄養学 尿中尿酸排泄量 尿 アルカリ化 application/pdf An increase in the incidence of hyperuriceamia associated with gout as well as phyertension, renaldiseases and cardiovascular disrases has been a public health concern. We examined the possibility of facilitated excretion of uric acid by change in urine pH by managing food materials. Within the framework of the Japanese government's health promotion program, we created recipes consisting of more protein and less fruit and vegetable-based food materials for H+-load (acid diet) and others composed of less protein but more fruit and vegetable-based materials (alkali diet). Healthy female students were enrolled in this 5-day study for each test. From a whole day collected urine, total volume, pH. organic acid, creatinine, uric acid and all cations (Na+, K+, Ca2+, Mg2+, NH4+) and anions (CI-, SO42-, PO4-) necessary for the estimation of acid-base balance were measured. Urine pH stabilized 3 days after switching from an ordinary daily diet to a specified regimens. The amount of acid generated ([SO42-]+organic acid-gut alkali) was linearly related with that of the excretion of acid (titratable acidity+[NH4+]-[HCO3-]), indicating that H+ in urine is generated by the metabolic degradation of food materials. Uric acid and excreted urine pH retained a linear relationship, where uric acid excrtion increased from 302 mg/d at pH 5.9 to 413 mg/d at pH 6.5, despite the fact that the alkali diet containes a smaller purine load than the acid diet. We conclude that alkalization of urine by eating nutritionally well-designed food is effective for removing uric acid from the body. 広島女学院大学 2010-12-21 jpn departmental bulletin paper VoR https://hju.repo.nii.ac.jp/records/740 0374-8057 広島女学院大学論集 60 141 149 https://hju.repo.nii.ac.jp/record/740/files/ronsyu60kanbaraseyama.pdf application/pdf 597.8 kB 2023-03-03